Not much is known about Betty Reagan, besides what little has been mentioned in conversations over the years. She and Henry had one child before Frank, Peter, who died of Leukemia at the age of 18 Months. After Frank was born, contrary to typical Irish-Catholic families, they chose not to have any more children. She also made Henry promise never to tell Frank because they didn't want him missing someone he never knew. Henry broke that promise, feeling that it was more important to tell the whole truth.
It is mentioned that she got sick and died, possibly from cancer. No photos of her are shown, aside from her headstone in the cemetery.